Railroad Lymphoma Aplastic Anemia

A bone marrow transplant is the only treatment to treat severe Aplastic anemia. It requires a healthy donor with blood type that is compatible, typically one of the siblings. Drugs that suppress the immune system, such as cyclosporine and anti-thymocyte globulin may aid in the process.

Aplastic anemia is more frequent in Railroad Emphysema workers due to exposure to chemicals, such as the chemical benzene that is used in locomotive machinists solvents as well as degreasers for car departments. If not treated promptly the condition can become fatal.

Expositions to the workplace

A lot of the chemicals and other materials Railroad Multiple Myeloma workers use in their jobs can be harmful to their health over long periods of time. These chemicals can be breathed in, consumed or absorbed by the skin. Certain of these chemicals such as benzene can cause serious and debilitating conditions such as leukemia and aplastic anemia.

Railroad Myelodysplastic Syndrome workers are often exposed to benzene from diesel exhaust. According to the Agency for Toxic Substances & Disease Registry Railroad Blood Cancer conductors, engineers, and yard workers have an increased risk of developing aplastic cerebrosis due to this exposure. Benzene can also be found in organic solvents such paint thinners, degreasers and fluids. In addition many herbicides, insecticides and paint removers contain benzene.

Aplastic anemia happens when the bone marrow ceases to produce new blood cells. The bone Marrow is a tissue that resembles a sponge that is made up of stem cells. These develop into red and white blood cells as well as platelets. Red blood cells transport oxygen to the tissues of the body. White blood cells aid in fighting infections and the platelets stay together to stop bleeding from tiny cuts or ruptures in blood vessels.

Aplastic anemia can be caused by a variety of factors which include radiation or chemotherapy treatments as well as certain autoimmune diseases such as rheumatoid arthritis. Certain individuals are more susceptible to the condition because of their genetics.

Signs and symptoms

Red blood cells transport oxygen throughout the entire body. A low number of these cells result in anemia, which can result in fatigue (tiredness), difficulty breathing, chest pains and cold hands or feet; and headaches. Anemia can be caused by a low hemoglobin level, which is a protein rich in iron that aids in the transport of oxygen through the blood. A deficiency in white blood cells could make you more prone to infections. Also, a shortage of platelets can result in bleeding from minor cuts or injuries.

The bone marrow is the place where the blood stem cells are produced. These cells give rise to red and white blood cells as well as platelets. Aplastic anemia is caused by a damaged blood stem cells that reside in the bone marrow. This can be caused either by cancer treatments like chemotherapy or radiation, or by auto-immune diseases such as lupus or eosinophilic faciitis, or paroxysmal nighttime hemoglobinuria.

Aplastic anemia symptoms can be difficult to recognize because they can resemble symptoms of other health conditions and may not appear for a long time. A doctor diagnoses aplastic anemia by conducting blood tests and executing an aspiration of bone marrow or biopsy. A bone marrow transplant is a possibility to help treat this disease.

Diagnosis

Aplastic anemia is caused by the destruction of stem cells in your bone marrow. If these stem cells are damaged, your body isn’t able to produce enough healthy blood. The most frequent cause of this problem is from autoimmune disease, where your immune system attacks and destroys your stem cells. Other causes are exposure to harmful chemicals or drugs, like chemotherapy. Certain genetic conditions, such as paroxysmal nocturnal hemoglobinuria and Railroad Aplastic Anemia Fanconi’s Anemia, could lead to this disorder.

If you suffer from aplastic anemia, your doctor will order blood tests to check the severity of the condition and also to determine the cause. The doctor will test for an insufficient number of platelets and red blood cells. The doctor will also examine your blood for vitamin B12 and folate, both of which are essential nutrients for healthy red blood cells.

Your doctor may prescribe growth factors or colony-stimulating agents like sargramostim (Leukine), filgrastim (Neupogen) and pegfilgrastim (Neulasta). These medications stimulate your bone marrow, so that it produces more blood cells. These medications are typically combined with immune suppressing medications. Your doctor will check your iron levels, as excessive iron can cause aplastic aneurism. If you are suffering from anemia due to these symptoms, your doctor may prescribe blood transfusions that include plates, red blood cells, and possibly folic or vitamin B12. If your anemia is severe and your doctor recommends a bone marrow transplant.

Treatment

Aplastic anemia is caused by damage to blood stem cells inside the bone marrow, the sponge-like tissue that creates blood within your bones. These stem cells make red blood cells as well as white blood cells and plates. The damage to blood stem cells may be the result of a variety of conditions and diseases. Certain medications, autoimmune conditions such as eosinophilic fasciitis, lupus and infections like HIV Hepatitis, hepatitis, Epstein-Barr, and exposure to chemicals or radioactivity are all possible causes. Aplastic anemia may be inherited in certain cases.

It is vital to get a diagnosis early because the symptoms of aplastic ahememia can be similar to symptoms of other diseases. If not treated, severe aplastic anemia can lead to serious infections or uncontrolled bleeding.

The treatment options for railroad aplastic anemia differ but the most efficient treatment is a bone marrow transplant. In this procedure healthy bone marrow cells are replaced by damaged marrow, and restore your blood cell count to normal. Until this treatment is available, doctors treat the symptoms of aplastic anemia with medications that suppress your immune system as well as increase the production of blood stem cells. These include immunosuppressants like azathioprine (Azulfidine(r)), methotrexate (Methotrexate(r)) and cyclosporine (Gengraf(r)). Bone marrow stimulating agents such as Neupogen, filgrastim, sargramostim (r) or epoetin (r) can also be employed. In some cases they can alleviate symptoms of aplastic anemia and prevent progression to myelodysplastic disorder or acute leukemia.